Ceruloplasmin

Ceruloplasmin is an acute phase protein. Incorporation of copper into Ceruloplasmin occurs during synthesis in the hepatocytes. After secretion from the liver, Ceruloplasmin migrates to copper requiring tissue, where copper is liberated and used. Decreased concentrations occur during recessive autosomal hepatolenticular degeneration (Wilson’s disease). On a pathochemical level, the disease occurs as a consequence of missing copper incorporation into the molecule due to a defective metalothionine.

Biorex Diagnostics manufactures Ceruloplasmin reagents designed for CA 180/270/400 Furuno/Daytona systems.