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Cystatin C (CysC) is an extraordinary protein known for its multifaceted functions. It serves as an early indicator for acute kidney injury (AKI), stands out as a superior gauge for both kidney transplant efficacy and the risk of transplant failure, and provides a more precise assessment of liver cirrhosis. Studies have indicated the potential of cystatin C in enhancing the diagnosis and prognosis of cardiovascular (CVD) risk as well as in oncology1.   Chronic Kidney Disease Prevalence Chronic kidney disease (CKD) represents a severe and progressive condition characterized by a gradual decline in kidney function. It poses a substantial global burden, affecting more than

Glucose-6-phosphate dehydrogenase (G6PDH) deficiency, an x-linked recessive disorder, stands out as one of the most widespread enzyme deficiencies globally. With over 400 million people affected worldwide, this condition is particularly prevalent in tropical and sub-tropical regions, notably in countries endemic to malaria such as those in Africa, the Middle East, and South Asia. 1, 2. Aetiology of G6PDH The Gd gene, situated on the X chromosome's long arm, is tasked with encoding the G6PDH enzyme. This enzyme resides in the cytoplasm of cells and plays a crucial role in the typical metabolism of carbohydrates. Particularly vital in erythrocytes, the G6PDH enzyme safeguards

Serum Indices Product Launch Introducing the all-new Serum Indices! The Biorex Serum Indices are the perfect tools to aid in the monitoring of instrument detection of lipaemia, icterus and haemolysis in specimens.   Introduction Analytical interference denotes any factor that impacts the accuracy, precision, or dependability of laboratory results, causing deviation from the true value of the substance being analyzed due to the presence of endogenous or exogenous substances. It is crucial to study the influence of endogenous substances like bilirubin, haemoglobin, and lipids on clinical laboratory tests to ensure the precision and dependability of test outcomes. Among the most common analytical interferences observed

Lactic Acidosis in Liver Cirrhosis  Love your liver this January with Biorex Diagnostics. Being the largest organ in the human body, the liver has a multitude of crucial functions essential for maintaining overall health. Despite its vital importance, it often doesn’t receive as much attention as other vital organs, like the lungs or heart 1. Acute and chronic hepatic insufficiency can lead to lactate accumulation and subsequently result in lactic acidosis 2.   Lactic Acid Lactic acid, also known as lactate, emerges when cells metabolize carbohydrates for energy. It's generated notably during intense physical efforts or instances when the body requires energy more rapidly

Respiratory Tract Infections The winter season is now upon us here in the northern hemisphere. As with each winter season, respiratory tract infections (RTIs) have begun to emerge. RTIs are the leading cause of death in childhood and the fourth most common cause of death in adults. They truly are a global health concern 1.   Prevalence of RTIs The first account of a winter respiratory infection epidemic was in 400BC in the ancient Greek record, “Book of Epidemics”, written by the Hippocrates. Since then, many respiratory viruses have been identified as the etiological agents of such epidemics. RTIs remain a significant public health

National Diabetes Month  Diabetes is a chronic disease characterised by insulin resistance either due to the pancreas’s inability to produce enough insulin or due to the body’s inability to use the insulin it produces effectively. Insulin is the hormone that is responsible for the regulation of blood glucose 1. Approximately 537 million adults, aged 20-79 years of age, are living with diabetes and is projected to rise to 643 million by 2030 and 783 million by 2045. Moreover, 240 million (1 in 2) adults are living with diabetes but it is undiagnosed and 541 million adults are at an increased risk

Men’s Health Testing This June, Biorex Diagnostics are focusing on Men’s Health Testing for Men’s Health Week (12th – 18th June 2023). Regular health screening for men is vital to aid in the early detection of several diseases, including: diabetes, heart disease and prostate cancer 1.   Diabetes Men are at an increased risk of developing diabetes from lower levels of weight gain and fat build up compared to women, meaning that men have a lower BMI than women when developing diabetes. Unlike women, men can experience unique effects from diabetes including erectile dysfunction (ED), recurrent gentile thrush and reduced muscle mass. Uncontrolled diabetes

Make May Purple For Stroke  Biorex Diagnostics are supporting Make May Purple for Stroke. Stroke is the result of a clot in a blood vessel leading to the brain, suddenly blocking or diminishing the blood supply to part of the brain. When the fresh blood supply containing oxygenated blood is deprived from any part of the body, cells become injured and may die. Whilst some cell injury is reversible, death to brain cells is permanent, and usually leaves a lasting disability 1.   Types of Stroke There are three main types of stroke: Embolic is caused by a circulating piece of a clot when lodges

Blood Grouping One of the most frequently performed clinical procedures to aid in improving tissue oxygen delivery in hospitalised patients in red blood cell (RBC) transfusion. Cross-matching is a mandatory test to meet the clinical needs of RBC transfusion through the examination of donor-recipient compatibility with antibodies and antigens of blood groups (see figure 1). An individual’s combination of antigens on the surface of the RBC determines the blood group, but it is typically of the ABO and the RH blood group systems. There are 43 blood group systems containing 345 antigens, recognised by the International Society of Blood Transfusion 1.   Figure

The Importance of Diagnostic Testing Healthcare starts with and depends on diagnostics, whether it’s cancer, diabetes, infectious diseases or serious health threats, diagnostics are at the front and centre. Diagnostics enable physicians and clinicians to gather the precise information to aid in the early detection, prevention and monitoring of diseases. Moreover, diagnostics are vital in optimising care pathways and in the creation and implementation of treatment plans. Despite this, diagnostics are greatly undervalued with many healthcare systems around the world sorely lacking in awareness of the importance of and capacity to integrate diagnostics 1.   The Role of Diagnostic Tests Diagnostic tests are used