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Beta-2-Microglobulin

β2-Microglobulin is a low molecular weight protein (11800D) found of the surface of all cells except erythrocytes and the trophoblastic layer of the placenta. It is a constituent of the light chain of human histocompatibility antigens HLA, A, B and C. β2M is found on T and B cells and in tumour associated transplantation antigens. β2M may control the expression of antigens on the cell surface and their biosynthesis.  In healthy individuals, β2M is synthesized at a rate of 9 mg/hours and is eliminated mostly by the kidneys. 

Biorex Diagnostics manufactures Beta-2-Microglobulin reagents designed for CA 180/270/400 Furuno/Daytona systems.

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Description

Product Name Details CAT.No Size
Beta-2 Microglobulin Suitable for CA 180/270/400 Furuno/ Daytona Series Reagents BXCF090A R1: 2 x 11ml R2: 2 x 4.3ml

 

Product Description

The Biorex Diagnostics Beta-2-Microglobulin Assay is an in vitro diagnostic test designed for the quantitative determination of β2-microglobulin in human serum, plasma, and urine. β2M is a low molecular weight protein that forms the light chain of HLA class I antigens and is essential for antigen presentation, immune regulation, and cellular turnover. Accurate measurement of β2M provides critical insights into renal function, immune system activity, and hematologic malignancies, making this assay a valuable tool for clinical laboratories and research settings.

Monitoring β2-microglobulin levels allows healthcare professionals to assess kidney performance, detect early signs of renal impairment, and monitor patients with chronic kidney disease. Elevated concentrations can indicate impaired renal clearance, active immune responses, or increased tumor burden in hematologic malignancies such as multiple myeloma and lymphoma. By providing precise and reproducible results, the Biorex β2M Assay supports early diagnosis, treatment planning, and ongoing patient monitoring, improving clinical decision-making and patient outcomes.

Key Features

  • Precise quantification of Beta-2-Microglobulin in serum, plasma, and urine
  • Supports assessment of renal function, immune activity, and tumor burden
  • Immunoturbidimetric method optimised for automated analyzers (CA 180/270/400 Furuno/Daytona)
  • Sensitive and specific detection of changes in cellular turnover and renal clearance
  • Reliable and reproducible performance across diverse laboratory platforms

Benefits
The Biorex β2-Microglobulin Assay provides consistent, clinically meaningful results, enabling laboratories to monitor kidney function, immune activation, and hematologic malignancies accurately. Its sensitivity and specificity allow early detection of changes in renal clearance and cellular turnover, while compatibility with automated analyzers ensures efficiency, reproducibility, and ease of integration into routine workflows.

Routine use of this assay supports nephrology, oncology, and immunology studies, as well as patient management in hospital and research settings. Its precision, reliability, and versatility make it an essential tool for clinical laboratories, improving diagnostic confidence and supporting evidence-based therapeutic decisions.

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Additional information

Storage

2-8°C