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C1 Esterase Inhibitor Immunoturbidimetric Reagents

The Biorex Diagnostics C1 Esterase Inhibitor assay is intended for the in vitro quantitative determination of human C1 Esterase Inhibitor in human serum and plasma.

C1 Esterase inhibitor is a protein mainly produced by the liver and is involved as a regulator in the complement system, kallikrein-kinin system and the coagulation cascade. C1 esterase inhibitor deficiency can cause intermittent angioedema and dermal swellings. Patients may present with acute abdominal pains and diagnosis may be confusing. The most common cause of C1 Esterase inhibitor deficiency is hereditary, due to mutations in genes controlling the coagulation cascade.

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Description

Product Name Format CAT.No Size
C1 Esterase Inhibitor Immunoturbidimetric without sample pre-dilution LS BXC0170A R1: 1 x 20ml R2: 1 x 4ml

 

Product Description

The Biorex Diagnostics C1 Esterase Inhibitor Assay is a ready-to-use reagent system for the quantitative determination of C1 esterase inhibitor in human serum and plasma, providing essential insight into complement system regulation and immune function. C1 esterase inhibitor is a key regulatory protein primarily produced by the liver, playing a critical role in controlling the complement system, kallikrein-kinin pathway, and coagulation cascade.

Deficiency or dysfunction of C1 esterase inhibitor is associated with hereditary angioedema (HAE), a condition characterised by recurrent episodes of swelling affecting the skin, gastrointestinal tract, and airways. Patients may present with symptoms such as unexplained abdominal pain or episodic oedema, making accurate laboratory assessment essential for diagnosis and management. Measurement of C1 esterase inhibitor levels supports the identification of hereditary and acquired deficiencies, aiding in differential diagnosis and clinical decision-making.

Key Features

  • Quantitative measurement in serum and plasma
  • Clinically relevant for diagnosing hereditary angioedema and complement system disorders
  • Supports evaluation of complement, coagulation, and kallikrein-kinin pathway regulation
  • Ready-to-use reagents simplify laboratory workflow and reduce preparation errors
  • Compatible with automated analysers and routine clinical laboratory protocols

Benefits
The Biorex Assay delivers precise, reliable, and reproducible results, supporting diagnosis, monitoring, and research applications in immunology and rare disease investigation. Its robust methodology enables accurate detection of C1 esterase inhibitor levels, assisting clinicians in identifying deficiencies and guiding appropriate patient management. By providing consistent and dependable measurements, the assay supports improved diagnostic confidence and effective clinical care.

This assay is particularly valuable in hospital laboratories, immunology departments, specialist diagnostic centres, and research institutions focused on complement disorders and rare diseases. Its ready-to-use format streamlines workflow, reduces variability, and ensures consistent performance across laboratory settings. Compatibility with automated analysers allows seamless integration into routine testing platforms, supporting efficient and reliable analysis.

In addition to clinical diagnostics, the Biorex Assay supports research into complement pathways, immune regulation, and genetic disorders, making it an essential tool for advancing understanding of angioedema and related conditions.

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Additional information

Storage

2-8°C